Code sample: Register multiple hotkeys such as Alt+D, Alt+C, etc.

Imports System.Runtime.InteropServices

Public Class Form1

Public Const MOD_ALT As Integer = &H1 'Alt key
Public Const WM_HOTKEY As Integer = &H312

_
Public Shared Function RegisterHotKey(ByVal hwnd As IntPtr, _
ByVal id As Integer, ByVal fsModifiers As Integer, _
ByVal vk As Integer) As Integer
End Function

_
Public Shared Function UnregisterHotKey(ByVal hwnd As IntPtr, _
ByVal id As Integer) As Integer
End Function

Private Sub Form1_Load(ByVal sender As System.Object, _
ByVal e As System.EventArgs) Handles MyBase.Load
RegisterHotKey(Me.Handle, 100, MOD_ALT, Keys.D)
RegisterHotKey(Me.Handle, 200, MOD_ALT, Keys.C)
End Sub

Protected Overrides Sub WndProc(ByRef m As System.Windows.Forms.Message)
If m.Msg = WM_HOTKEY Then
Dim id As IntPtr = m.WParam
Select Case (id.ToString)
Case "100"
MessageBox.Show("You pressed ALT+D key combination")
Case "200"
MessageBox.Show("You pressed ALT+C key combination")
End Select
End If
MyBase.WndProc(m)
End Sub

Private Sub Form1_FormClosing(ByVal sender As System.Object, _
ByVal e As System.Windows.Forms.FormClosingEventArgs) _
Handles MyBase.FormClosing
UnregisterHotKey(Me.Handle, 100)
UnregisterHotKey(Me.Handle, 200)
End Sub

End Class